Pre-heat the oven to 400 degrees.
You can make this entire dish in a stove top/oven safe casserole, braiser, or pot with a lid. If you do not have this, you can brown the meat in a skillet and transfer everything to an oven safe casserole pan with a lid or use aluminum foil.
Melt the fat in a large oven safe casserole pan or braiser over medium high heat, and brown the beef with the sea salt. Add the Italian seasoning, onion & garlic powders, and pepper, and cook for 2 minutes.
Turn off the heat, and add the nutritional yeast, pumpkin puree, bone broth, tomato sauce, spinach, and pasta. Stir to combine and top with cheese.
Put the lid on your casserole, and bake at 400 degrees for 30 minutes. I like to take the lid off at the end and put it under the broiler for a few minutes to brown the top and crisp up any edges too!